The Cathedral Panthers boys basketball team competes in the Catholic Central League and fields teams at four levels: middle school, freshman, junior varsity (JV), and varsity. The Panthers have established themselves as one of the premier small school boys basketball programs in Massachusetts. The Panthers have recently appeared in five Division IV State Championship games (2006, 2007, 2009, 2010, 2012). The boys team took the State Championship title in 2006, 2007, and 2009. They were also South Sectional Finalists in 2011, South Sectional D4 Champions in 2017, and Division 4 State Semi-Finalists in 2014.